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Hazardous Chemical Details

Cas Number 27083-27-8
Chemical Name polyhexamethylene biguanide hydrochloride
Chemical Synonym Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride
PHMB
Hazard Category Acute toxicity (inhalation) - category 2
Acute toxicity (ingestion) - category 4
Eye damage – category 1
Skin sensitisation – category 1
Carcinogenicity – category 2
Specific target organ toxicity (repeated exposure) – category 1
Hazardous to the aquatic environment (acute) – category 1
Hazardous to the aquatic environment (chronic) – category 1
Hazard Statement H330 (Fatal if inhaled)
H302 (Harmful if swallowed)
H318 (Causes serious eye damage)
H317 (May cause an allergic skin reaction)
H351 (Suspected of causing cancer)
H372 (Causes damage to organs through prolonged or repeated exposure through inhalation)
H410 (Very toxic to aquatic life with long-lasting effects)
Pictogram Pictogram of Health Hazard GHS08 (Health Hazard)
Pictogram of Skull and Crossbones GHS06 (Skull and Crossbones)
Pictogram of Corrosion GHS05 (Corrosion)
Pictogram of Environment GHS09 (Environment)
Signal Word Danger
Cut-offs

M = 10 (acute)
M = 10 (chronic)
Notes 8 (The tables in schedule 6 of the WHS regulations replace some tables in the GHS, this may affect the cut off concentrations for this chemical.)
Sources N (The classification information for this entry was provided by the National Industrial Chemical Notification and Assessment Scheme)
EU (Classification information for chemical is taken from the European Union’s Classification, Labelling and Packaging (CLP) Regulation.)

Hazardous Chemical History

Date Description
03/05/2021 Pictogram modified from
[GHS08,GHS06,GHS05,GHS09]
to
[GHS05,GHS06,GHS08,GHS09]
03/05/2021 CutOffs modified from
[M = 10 (acute)
M = 10 (chronic)]
to
[

M = 10 (acute)
M = 10 (chronic)

]
Pictogram modified from
[GHS08,GHS06,GHS05,GHS09]
to
[GHS05,GHS06,GHS08,GHS09]
Hazard Statement modified from
[H330 Fatal if inhaled;
H302 Harmful if swallowed;
H318 Causes serious eye damage;
H317 May cause an allergic skin reaction;
H351 Suspected of causing cancer;
H372 Causes damage to organs through prolonged or repeated exposure;
H410 Very toxic to aquatic life with long-lasting effects]
to
[H330 Fatal if inhaled;
H302 Harmful if swallowed;
H318 Causes serious eye damage;
H317 May cause an allergic skin reaction;
H351 Suspected of causing cancer;
H372 Causes damage to organs through prolonged or repeated exposure through inhalation;
H410 Very toxic to aquatic life with long-lasting effects]
03/05/2021 CutOffs modified from
[]
to
[M = 10 (acute)
M = 10 (chronic)]
Synonym modified from
[Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride;
PHMB]
to
[Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride;
PHMB]
Hazard Category modified from
[HC060:Acute toxicity – category 2,
HC062:Acute toxicity – category 4,
HC085:Eye damage – category 1,
HC092:Skin sensitisation – category 1,
HC102:Carcinogenicity – category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1,
HC115:Hazardous to the aquatic environment (acute) – category 1,
HC118:Hazardous to the aquatic environment (chronic) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC072:Acute toxicity (ingestion) - category 4,
HC085:Eye damage – category 1,
HC092:Skin sensitisation – category 1,
HC102:Carcinogenicity – category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1,
HC115:Hazardous to the aquatic environment (acute) – category 1,
HC118:Hazardous to the aquatic environment (chronic) – category 1]

Pictogram modified from
[GHS08,GHS06,GHS05,GHS09]
to
[GHS05,GHS06,GHS08,GHS09]
Notes modified from
[]
to
[8 ]
05/06/2018 Synonym modified from
[Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride]
to
[Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride;
PHMB]
Pictogram modified from
[GHS05,GHS06,GHS08,GHS09]
to
[GHS08,GHS06,GHS05,GHS09]
Hazard Statement modified from
[H330 Fatal if inhaled;
H302 Harmful if swallowed;
H318 Causes serious eye damage;
H317 May cause an allergic skin reaction;
H351 Suspected of causing cancer;
H372 Causes damage to organs through prolonged or repeated exposure;
H410 Very toxic to aquatic life with long-lasting effects]
to
[H330 ;
H302 ;
H318 ;
H317 ;
H351 ;
H372 ;
H410 ]
Notes modified from
[8]
to
[]
09/05/2018 Synonym modified from
[]
to
[Guanidine, N,N'''-1,6-hexanediylbis[N'-cyano-, polymer with 1,6-hexanediamine, hydrochloride]
Hazard Category modified from
[HC102:Carcinogenicity – category 2,
HC062:Acute toxicity – category 4,
HC111:Specific target organ toxicity (repeated exposure) – category 1,
HC085:Eye damage – category 1,
HC094:Skin sensitisation – category 1B,
HC115:Hazardous to the aquatic environment (acute) – category 1,
HC118:Hazardous to the aquatic environment (chronic) – category 1]

to
[HC060:Acute toxicity – category 2,
HC062:Acute toxicity – category 4,
HC085:Eye damage – category 1,
HC092:Skin sensitisation – category 1,
HC102:Carcinogenicity – category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1,
HC115:Hazardous to the aquatic environment (acute) – category 1,
HC118:Hazardous to the aquatic environment (chronic) – category 1]

Pictogram modified from
[GHS05,GHS07,GHS08,GHS09]
to
[GHS05,GHS06,GHS08,GHS09]
Hazard Statement modified from
[H351 Suspected of causing cancer;
H302 Harmful if swallowed;
H372 Causes damage to the repiratory tract through prolonged or repeated inhalation;
H318 Causes serious eye damage;
H317 May cause an allergic skin reaction;
H410 Very toxic to aquatic life with long-lasting effects]
to
[H330 ;
H302 ;
H318 ;
H317 ;
H351 ;
H372 ;
H410 ]
Sources modified from
[EU]
to
[N,EU]
20/12/2016 Chemical Added



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