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| Cas Number | 101-68-8 |
| Chemical Name | Benzene, 1,1'-methylenebis[4-isocyanato- |
| Chemical Synonym |
4,4'-methylenediphenyl diisocyanate diphenylmethane-4,4'-diisocyanate methylene bisphenyl isocyanate (MDI) 4,4'-Methylenebis(phenyl isocyanate) |
| Hazard Category |
Acute toxicity – category 2 Carcinogenicity – category 2 Eye irritation – category 2A Skin irritation – category 2 Specific target organ toxicity (repeated exposure) – category 1 Respiratory sensitisation – category 1 Skin sensitisation – category 1 Specific target organ toxicity (single exposure) – category 3 |
| Hazard Statement |
H330 (Fatal if inhaled) H351 (Suspected of causing cancer) H319 (Causes serious eye irritation) H315 (Causes skin irritation) H335 (May cause respiratory irritation) H372 (Causes damage to organs through prolonged or repeated exposure) H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled) H317 (May cause an allergic skin reaction) |
| Pictogram |
GHS06 (Skull and Crossbones) 
GHS08 (Health Hazard) |
| Signal Word | Danger |
| Cut-offs | |
| Notes |
8 (The tables in schedule 6 of the WHS regulations replace some tables in the GHS, this may affect the cut off concentrations for this chemical.) C (Some organic substances may be marketed either in a specific isomeric form or as a mixture of several isomers.In this case the supplier should state on the label whether the substance is a specific isomer or a mixture of isomers.) |
| Sources |
N (The classification information for this entry was provided by the National Industrial Chemical Notification and Assessment Scheme) EU (Classification information for chemical is taken from the European Union’s Classification, Labelling and Packaging (CLP) Regulation.) |
Hazardous Chemical History
| Date | Description |
|---|---|
| 12/02/2019 |
Synonym modified from [4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate] to [4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; methylene bisphenyl isocyanate (MDI); 4,4′-Methylenebis(phenyl isocyanate)] Notes modified from [8,C] to [C,8] |
| 25/11/2016 |
Hazard Category modified from [HC060:Acute toxicity – category 2, HC102:Carcinogenicity – category 2, HC087:Eye irritation – category 2A, HC083:Skin irritation – category 2, HC111:Specific target organ toxicity (repeated exposure) – category 1, HC089:Respiratory sensitisation – category 1, HC092:Skin sensitisation – category 1] to [HC060:Acute toxicity – category 2, HC102:Carcinogenicity – category 2, HC087:Eye irritation – category 2A, HC083:Skin irritation – category 2, HC111:Specific target organ toxicity (repeated exposure) – category 1, HC089:Respiratory sensitisation – category 1, HC092:Skin sensitisation – category 1, HC110:Specific target organ toxicity (single exposure) – category 3] |
| 23/06/2016 | Chemical Added |