Hazardous Chemical Information System (HCIS)



Hazardous Chemical Details

Cas Number 67-97-0
Chemical Name colecalciferol
Chemical Synonym cholecalciferol
vitamin D3
9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3.beta.,5Z,7E)-
Hazard Category Specific target organ toxicity (repeated exposure) – category 1
Acute toxicity (ingestion) - category 3
Acute toxicity (dermal) - category 3
Acute toxicity (inhalation) - category 2
Hazard Statement H372 (Causes damage to organs through prolonged or repeated exposure)
H301 (Toxic if swallowed)
H311 (Toxic in contact with skin)
H330 (Fatal if inhaled)
Pictogram Pictogram of Skull and Crossbones GHS06 (Skull and Crossbones)
Pictogram of Health Hazard GHS08 (Health Hazard)
Signal Word Danger
Cut-offs
Notes 17 (Generic cut off concentrations also apply to this chemical in addition to the specific cut off concentration(s) above. Refer to the generic cut off concentration table on the Reference Information page of HCIS (http://hcis.safeworkaustralia.gov.au/UserGuide).)
Sources EU (Classification information for chemical is taken from the European Union’s Classification, Labelling and Packaging (CLP) Regulation.)
A (The classification information for this entry was provided by the Australian Industrial Chemicals Introduction Scheme)

Hazardous Chemical History

Date Description
30/08/2023 CutOffs modified from
[

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%

]
to
[]
30/08/2023 CutOffs modified from
[

Inhalation: ATE = 0.05 mg/L; (dusts/mists)
Dermal: ATE = 50 mg/kg bw;
Oral: ATE = 35 mg/kg bw;

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%

]
to
[

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%

]
18/08/2021 Synonym modified from
[cholecalciferol;
vitamin D3]
to
[cholecalciferol;
vitamin D3;
9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3.beta.,5Z,7E)-]
Hazard Category modified from
[HC070:Acute toxicity (ingestion) - category 2,
HC065:Acute toxicity (inhalation) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC071:Acute toxicity (ingestion) - category 3,
HC076:Acute toxicity (dermal) - category 3,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

Hazard Statement modified from
[H330 Fatal if inhaled;
H310 Fatal in contact with skin;
H300 Fatal if swallowed;
H372 Causes damage to organs through prolonged or repeated exposure]
to
[H372 Causes damage to organs through prolonged or repeated exposure;
H301 Toxic if swallowed;
H311 Toxic in contact with skin;
H330 Fatal if inhaled]
Sources modified from
[EU]
to
[EU,A]
18/08/2021 Hazard Category modified from
[HC070:Acute toxicity (ingestion) - category 2,
HC065:Acute toxicity (inhalation) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC070:Acute toxicity (ingestion) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

Notes modified from
[]
to
[17 ]
18/08/2021 CutOffs modified from
[Inhalation: ATE = 0.05 mg/L; (dusts/mists)
Dermal: ATE = 50 mg/kg bw;
Oral: ATE = 35 mg/kg bw;

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%]
to
[

Inhalation: ATE = 0.05 mg/L; (dusts/mists)
Dermal: ATE = 50 mg/kg bw;
Oral: ATE = 35 mg/kg bw;

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%

]
Hazard Category modified from
[HC070:Acute toxicity (ingestion) - category 2,
HC065:Acute toxicity (inhalation) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC070:Acute toxicity (ingestion) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

Notes modified from
[8 ]
to
[]
18/08/2021 CutOffs modified from
[]
to
[Inhalation: ATE = 0.05 mg/L; (dusts/mists)
Dermal: ATE = 50 mg/kg bw;
Oral: ATE = 35 mg/kg bw;

Specific target organ toxicity (repeated exposure) - category 1 (H372): concentration >= 3%;
Specific target organ toxicity (repeated exposure) - category 2 (H373): 0.3% <= concentration < 3%]
Synonym modified from
[ cholecalciferol;
vitamin D3]
to
[cholecalciferol;
vitamin D3]
Hazard Category modified from
[HC070:Acute toxicity (ingestion) - category 2,
HC065:Acute toxicity (inhalation) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC070:Acute toxicity (ingestion) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]
10/06/2020 Synonym modified from
[ Vitamin D3;
Cholecalciferol]
to
[ cholecalciferol;
vitamin D3]
Hazard Category modified from
[HC060:Acute toxicity – category 2,
HC061:Acute toxicity – category 3,
HC061:Acute toxicity – category 3,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

to
[HC065:Acute toxicity (inhalation) - category 2,
HC070:Acute toxicity (ingestion) - category 2,
HC075:Acute toxicity (dermal) - category 2,
HC111:Specific target organ toxicity (repeated exposure) – category 1]

Hazard Statement modified from
[H330 Fatal if inhaled;
H311 Toxic in contact with skin;
H301 Toxic if swallowed;
H372 Causes damage to organs through prolonged or repeated exposure]
to
[H330 ;
H310 ;
H300 ;
H372 ]
19/07/2019 Synonym modified from
[ Vitamin D3]
to
[ Vitamin D3;
Cholecalciferol]
23/06/2016 Chemical Added